What is Zinaxin?

Centuries ago the Chinese discovered a natural remedy for relieving joint discomfort without any of the dangerous side effects of modern anti-inflammatory drugs like Celebrex and Ibuprofen.

Today that ancient remedy has arrived in the U.S. in the form of an all-natural dietary supplement, Zinaxin™.

Zinaxin™ is based on extracts of a rare, bitter ginger root harvested at only certain times of the year in a remote region of China.

Rigorously tested around the world, Zinaxin™ has been the subject of three clinical trials and massive scientific testing abroad involving over a thousand subjects, all of which "have confirmed that those Chinese ancestors were right," said Zinaxin's inventor Dr. Morton Weidner, a Danish biochemist with a Ph.D. in pharmacology and a chemical engineer. Zinaxin™, which contains the same ginger extracts that the ancient Chinese found effective, has been shown in all the studies to help in promoting joint health with complete safety.

Now all Americans can discover what hundreds of thousands of people around the world have discovered, from ordinary people in Australia and Europe to Olympic champions like Carl Lewis, a strong believer in Zinaxin's effectiveness.

Contrary to popular belief, Dr. John Taylor, noted rheumatologist and arthritis expert affiliated with the Cleveland Clinic believes that unhealthy joints are more than just a problem linked with aging. "Joint health is a problem that affects more than 80 million people a year in the U.S., including a large percentage of young, active adults," Taylor said.

Dr. Taylor has used Zinaxin™ on more than 500 of his patients, with nearly 80 percent of them reporting significant improvement in their conditions.

How can Ginger be of use to someone with serious arthritis Pain?

NSAIDs are a valuable treatment in many rheumatic disorders as well as growing in use for acute and non-inflammatory conditions due to their pain killing effect. However, prolonged use of NSAIDs does expose patients to unpleasant side effects.

Many of the clinical effects of NSAIDs are a result of inhibition of pain promoting prostaglandins. However, NSAID-induced inhibition of GI mucosal PG synthesis is thought to be a major mechanism responsible for the GI toxicity of these therapeutic agents.

Inflamations start when the immune cells start one or more of several cascade reactions that yield inflamatory mediators. Ginger inhibits, in part the 5-lipogenase enzyme and its inflammatory cascade reaction. Ginger also partly blocks the COX enzymes, but unlike the synthetic NSAIDS, ginger does not fully block COX-1 and does not create gastric bleeding or stomach upset.

Ginger has been found to lessen stomach acid and to lessen ulcer form stomach irritants.

Studies have shown that Zinaxin does not cause gastric irritation. Furthermore, various studies indicate that Zinaxin has no irritant or ulcerogenic effects in-vivo.

Ginger acts to maintain a healthy balance of inflammatory mediators.

Ginger (Zingiber officinale) is mostly known to us in the West as a spice and a flavor. In China, however, it has been used for thousands of years for medicinal purposes, such as nausea, stomachache, rheumatism and toothache. Modern research has found ginger to be a powerful anti-oxidant and to have strong anti-inflammatory effects.

The pharmacologically active components of the ginger root are thought to be aromatic ketones known as gingerols. These have been shown in experimental studies to inhibit both the cyclooxygenase and lipoxygenase pathways and the production of prostaglandins, thromboxane and leukotrienes (Kiuchi F et al., 1992; Srivastava KC, 1986; Flynn DL et al., 1986), just as the NSAIDs do. No significant side effects have been reported.

Ginger oil is obtained by steam distillation of dried ginger root. In an experimental study on rats (Sharma JN et al., 1997), arthritis was induced in the knee and paw by injection of bacilli, leading to inflammation. One group of rats was also given ginger oil by mouth for 28 days starting the day before the injection. The rats given ginger oil had less than half the knee and paw inflammation compared to the controls.

Ginger reduces runaway inflammation through its antioxidant activity

The oxidative "explosion" results in, amongst other things, free radicals which play a role in tissue destruction and the inflammatory process. Results show that Zinaxin apart from its pain relieving effect, also counteracts the aggravation caused by the oxidative burst.

This oxidative explosion in granulocytes plays a role in the inflammatory process. The inhibitory effect of Zinaxin on the oxidative burst is much stronger than large doses of Ibuprofen which has no significant effect.

Pharmacokinetic studies indicate that Zinaxin is absorbed much faster and reaches a higher level in the blood than control extracts. This higher level is maintained for a longer period of time (2.2 times higher absorption).